CEPS: ORdmD16 Class Reference

Detailed Description

O'Hara - Rudy CiPA v1.0 (2017) ionic model.

Reference:

https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002061#s5 (pdf to download)

Units of currents and capacity are in uA and uF per mm2 !

Definition at line 45 of file ORdmD16.hpp.

#include <ORdmD16.hpp>

Inheritance diagram for ORdmD16:

[legend]

Public Types
enum class	Type { Endo , MidMyo , Epi }
	Model variant selector. More...

Public Member Functions
	ORdmD16 (const Type &type, Unknown u, const CepsSet< CepsAttribute > &attrs={}, InputParameters params=nullptr)
	Constructor (sets constants) More...

	~ORdmD16 ()=default
	Destructor. More...

void	getInitialCondition (CepsReal v, CepsReal y) const final
	Sets initial values of state variables and transmembrane voltage for a single point. Arrays y,dty must be preallocated with size m_nStateVars. More...

void	computeRates (CepsReal t, CepsReal y, CepsReal v, CepsReal dtyL, CepsReal dtyNL, CepsReal dtv, DegreeOfFreedom dof) const override
	Get the linear and non linear part of the evolution function f. Also computes the ionic current. More...

Public Member Functions inherited from AbstractIonicModel
virtual	~AbstractIonicModel ()
	Destructor. More...

CepsString	getName () const
	Name of the solver for info display. More...

Unknown *	getUnknown () const
	The unknown object of the transmembrane voltage. More...

ScalarField< DegreeOfFreedom > *	getCm () const
	Link to Cm coefficient of PDE. More...

void	setCm (ScalarField< DegreeOfFreedom > *)
	Link to Cm coefficient of PDE. More...

CepsReal	getPaperCm (CepsBool cepsUnit) const
	Get the original value of Cm used in paper. More...

CepsReal	getPaperStim () const
	Get the original amplitude of stimulation, converted into ceps units. More...

void	addStimulation (ScalarSourceTerm *stim)
	Links the model to a stimulation function, needed for computation of _ki. More...

CepsReal	getStimulation (DegreeOfFreedom *x, CepsReal t) const
	Get the sum of all stimulations at time t and dof x. More...

virtual CepsUInt	getNbStateVariables () const
	The number of state variables, except transmembrane voltage. More...

CepsString	getStateVariableName (CepsUInt i) const
	Gives the name of the i-th state variable. More...

virtual CepsReal	convertVoltageFromCepsUnit (const CepsReal &v) const
	Convert voltage from ceps units (mV) to ionic model units. Does nothing by default. More...

virtual CepsReal	convertVoltageToCepsUnit (const CepsReal &v) const
	Convert voltage from ionic model units to ceps units (mV). Does nothing by default. More...

virtual CepsReal	convertDtvToCepsUnit (const CepsReal &dtv) const
	Convert current from ionic model units to ceps units (mV ms-1). Does nothing by default. More...

virtual CepsReal	convertCurrentFromCepsUnit (const CepsReal &i) const
	Convert current from ionic model units to ceps units (uA per cm2). Does nothing by default. More...

virtual CepsReal	convertCmFromCepsUnit (const CepsReal &cm) const
	Convert capacitance from ceps units (uF/cm2) to ionic model units. Does nothing by default. More...

virtual CepsReal	convertCmToCepsUnit (const CepsReal &cm) const
	Convert capacitance from ionic model units to ceps units (uF/cm2). Does nothing by default. More...

void	setLinkedSolver (IonicSolver *solver)
	Links instance to solver. More...

IonicSolver *	getLinkedSolver () const
	Get link to solver. More...

Public Member Functions inherited from ceps::HoldsAttributes
	HoldsAttributes (const CepsSet< CepsAttribute > &attributes)
	Constructor with any number of attributes. More...

	HoldsAttributes (const CepsVector< CepsAttribute > &attributes)
	Constructor with any number of attributes. More...

	HoldsAttributes (CepsAttribute *attributes, const CepsUInt &n)
	Constructor with any number of attributes. More...

	HoldsAttributes ()=default
	Default constructor. More...

	HoldsAttributes (const HoldsAttributes &)=default
	Assignement operator. More...

	HoldsAttributes (HoldsAttributes &&) noexcept=default
	Copy constructor. More...

virtual	~HoldsAttributes ()=default
	Destructor. More...

HoldsAttributes &	operator= (const HoldsAttributes &)=default
	Assignment operator. More...

HoldsAttributes &	operator= (HoldsAttributes &&) noexcept=default
	Assignment operator. More...

CepsUInt	getNumberOfAttributes () const
	Returns number of attributes of the entity. More...

CepsSet< CepsAttribute > &	getAttributes ()
	Returns the attributes of the entity. More...

const CepsSet< CepsAttribute > &	getAttributes () const
	Returns the attributes of the entity, const version. More...

void	setAttributes (const CepsVector< CepsAttribute > &attributes)
	Sets the attributes of the entity. More...

void	setAttributes (const CepsSet< CepsAttribute > &attributes)
	Sets the attributes of the entity. More...

void	setAttributes (const CepsAttribute *attributes, const CepsUInt &n)
	Sets the attributes of the entity. More...

template<class _It >
void	setAttributes (_It first, _It last)
	Sets the attributes of the entity. More...

void	addAttribute (const CepsAttribute &name)
	Adds an attribute to the entity. More...

void	addAttributes (const CepsVector< CepsAttribute > &attributes)
	Adds several attributes to the entity. More...

void	addAttributes (const CepsSet< CepsAttribute > &attributes)
	Adds several attributes to the entity. More...

void	addAttributes (const CepsAttribute *attributes, const CepsUInt &n)
	Adds several attributes to the entity. More...

template<class _It >
void	addAttributes (_It first, _It last)
	Adds several attributes to the entity. More...

void	removeAttribute (const CepsAttribute &name)
	Removes an attribute from the entity. More...

void	removeAttributes (const CepsSet< CepsAttribute > &attributes)
	Removes several attributes from the entity. More...

void	removeAttributes (const CepsVector< CepsAttribute > &attributes)
	Removes several attributes from the entity. More...

void	removeAttributes (const CepsAttribute *attributes, const CepsUInt &n)
	Removes several attributes from the entity. More...

template<class _It >
void	removeAttributes (_It first, _It last)
	Removes several attributes from the entity. More...

void	clearAttributes ()
	Removes all attributes from the entity. More...

CepsBool	hasAttribute (const CepsAttribute &name) const
	Tells if the entity has the attribute in argument. More...

CepsBool	hasAllAttributes (const CepsVector< CepsAttribute > &attributes) const
	Tells if the entity has all the attributes in argument. More...

CepsBool	hasAllAttributes (const CepsAttribute *attributes, const CepsUInt &n) const
	Tells if the entity has all the attributes in argument. More...

template<class _It >
CepsBool	hasAllAttributes (_It first, _It last) const
	Tells if the entity has all the attributes in argument. More...

CepsBool	hasOneOfAttributes (const CepsSet< CepsAttribute > &attributes) const
	Tells if the entity has one of the attributes in argument. More...

CepsBool	hasOneOfAttributes (const CepsVector< CepsAttribute > &attributes) const
	Tells if the entity has one of the attributes in argument. More...

CepsBool	hasOneOfAttributes (const CepsAttribute *attributes, const CepsUInt &n) const
	Tells if the entity has one of the attributes in argument. More...

template<class _It >
CepsBool	hasOneOfAttributes (_It first, _It last) const
	Tells if the entity has one of the attributes in argument. More...

CepsBool	hasUniversalAttribute () const
	Detect if the current entity has the attribute universal. More...

void	reset ()
	Equivalent to HoldsAttributes::clear() More...

Protected Member Functions
void	setupWithParameters (InputParameters *p)
	Sets the constants and the space dependant parameters from text inputs. More...

void	computeINa (CepsReal INa, CepsReal iNaL, CepsReal v, CepsReal y, CepsReal dtyLin, CepsReal *dtyNLin, CepsReal fraction) const
	Fast Na+ current and Late Na+ current. More...

void	computeIto (CepsReal Ito, CepsReal v, CepsReal y, CepsReal dtyLin, CepsReal dtyNLin, CepsReal fraction) const
	Transient outward K+ current. More...

void	computeICa (CepsReal ICaL, CepsReal ICaNa, CepsReal ICaK, CepsReal v, CepsReal y, CepsReal dtyLin, CepsReal dtyNLin, CepsReal fraction) const
	L-type Ca2+ channel. More...

void	computeIKr (CepsReal IKr, CepsReal v, CepsReal y, CepsReal dtyLin, CepsReal dtyNLin) const
	Rapid Delayed Rectifier K+ Current. More...

void	computeIKs (CepsReal IKs, CepsReal v, CepsReal y, CepsReal dtyLin, CepsReal dtyNLin) const
	Slow Delayed Rectifier K+ Current. More...

void	computeIK1 (CepsReal IK1, CepsReal v, CepsReal y, CepsReal dtyLin, CepsReal dtyNLin) const
	Inward Rectifier K+ Current. More...

void	computeINaCa (CepsReal INaCa_i, CepsReal INaCa_ss, CepsReal v, CepsReal *y) const
	Na+/Ca2+ exchanger. More...

CepsReal	computeINaCaInternal (CepsReal v, CepsReal na, CepsReal ca) const
	Internal function to avoid duplication. More...

void	computeINaK (CepsReal INaK, CepsReal v, CepsReal y) const
	Sodium/Potassium ATPase Current. More...

void	computeBgCurrents (CepsReal IKb, CepsReal INab, CepsReal ICab, CepsReal v, CepsReal y) const
	Background currents. More...

void	computeIPCa (CepsReal IPCa, CepsReal y) const
	Sarsolemmal calcium pump current. More...

void	computeJrel (CepsReal Jrel, CepsReal ICaL, CepsReal y, CepsReal dtyLin, CepsReal dtyNLin, CepsReal fraction) const
	SR Calcium Release Flux, via Ryanodine Receptor. More...

void	computeJup (CepsReal Jup, CepsReal y, CepsReal fraction) const
	Calcium Uptake via SERCA Pump. More...

Protected Member Functions inherited from AbstractIonicModel
	AbstractIonicModel (Unknown *u, const CepsSet< CepsAttribute > &attrs={})
	Called only by derived classes. More...

CepsReal	getCmInternal (CepsReal t, DegreeOfFreedom *dof) const
	Get either the value of cm on dof, or the default value from the paper. More...

CepsReal	sigmoid (CepsReal x, CepsReal c, CepsReal k) const
	Function often used in rates evaluations. More...

CepsReal	gaussian (CepsReal x, CepsReal c, CepsReal s) const
	Function often used in rates evaluations. More...

CepsReal	uOverExpm1u (CepsReal u) const
	Functions u/(1-exp(u)) that returns 2 (from expansion around 0) More...

Protected Attributes
Type	m_type
	Celltype selector (endo, epi, midmyo) More...

Protected Attributes inherited from AbstractIonicModel
Unknown *	m_unknown
	Pointer on unknown on which the model applies. More...

CepsReal *	m_constants
	Constant parameters of the model, from inputs. More...

CepsReal *	m_dconstants
	Constant parameters of the model, computed from others. More...

ScalarField< DegreeOfFreedom > *	m_cm
	Link to coef Cm of the PDE, for unit conversion. More...

CepsReal	m_paperCm
	Original value of Cm. More...

CepsReal	m_paperStim
	Original stim amplitude. More...

CepsVector< ScalarSourceTerm * >	m_stims
	Link to excitations. More...

CepsUInt	m_nStateVars
	Dimensionality of the ODE system, -1 for vm. More...

CepsVector< CepsString >	m_stateVarNames
	Names of state variables. More...

CepsString	m_name
	A label for display. More...

IonicSolver *	m_solver
	Link to solver, set when solver is created. More...

Protected Attributes inherited from ceps::HoldsAttributes
CepsSet< CepsAttribute >	m_attributes
	The attributes held by the entity. More...

Static Protected Attributes
static constexpr const CepsInt	_nai = 0
	Index alias. More...

static constexpr const CepsInt	_nass = 1
	Index alias. More...

static constexpr const CepsInt	_ki = 2
	Index alias. More...

static constexpr const CepsInt	_kss = 3
	Index alias. More...

static constexpr const CepsInt	_cai = 4
	Index alias. More...

static constexpr const CepsInt	_cass = 5
	Index alias. More...

static constexpr const CepsInt	_cansr = 6
	Index alias. More...

static constexpr const CepsInt	_cajsr = 7
	Index alias. More...

static constexpr const CepsInt	_m = 8
	Index alias. More...

static constexpr const CepsInt	_hf = 9
	Index alias. More...

static constexpr const CepsInt	_hs = 10
	Index alias. More...

static constexpr const CepsInt	_j = 11
	Index alias. More...

static constexpr const CepsInt	_hsp = 12
	Index alias. More...

static constexpr const CepsInt	_jp = 13
	Index alias. More...

static constexpr const CepsInt	_mL = 14
	Index alias. More...

static constexpr const CepsInt	_hL = 15
	Index alias. More...

static constexpr const CepsInt	_hLp = 16
	Index alias. More...

static constexpr const CepsInt	_a = 17
	Index alias. More...

static constexpr const CepsInt	_iF = 18
	Index alias. More...

static constexpr const CepsInt	_iS = 19
	Index alias. More...

static constexpr const CepsInt	_ap = 20
	Index alias. More...

static constexpr const CepsInt	_iFp = 21
	Index alias. More...

static constexpr const CepsInt	_iSp = 22
	Index alias. More...

static constexpr const CepsInt	_d = 23
	Index alias. More...

static constexpr const CepsInt	_ff = 24
	Index alias. More...

static constexpr const CepsInt	_fs = 25
	Index alias. More...

static constexpr const CepsInt	_fcaf = 26
	Index alias. More...

static constexpr const CepsInt	_fcas = 27
	Index alias. More...

static constexpr const CepsInt	_jca = 28
	Index alias. More...

static constexpr const CepsInt	_nca = 29
	Index alias. More...

static constexpr const CepsInt	_ffp = 30
	Index alias. More...

static constexpr const CepsInt	_fcafp = 31
	Index alias. More...

static constexpr const CepsInt	_xrf = 32
	Index alias. More...

static constexpr const CepsInt	_xrs = 33
	Index alias. More...

static constexpr const CepsInt	_xs1 = 34
	Index alias. More...

static constexpr const CepsInt	_xs2 = 35
	Index alias. More...

static constexpr const CepsInt	_xk1 = 36
	Index alias. More...

static constexpr const CepsInt	_Jrelnp = 37
	Index alias. More...

static constexpr const CepsInt	_Jrelp = 38
	Index alias. More...

static constexpr const CepsInt	_CaMKt = 39
	Index alias. More...

static constexpr const CepsInt	_IKr_factor = 0
	Index alias. More...

static constexpr const CepsInt	_IKs_factor = 1
	Index alias. More...

static constexpr const CepsInt	_IK1_factor = 2
	Index alias. More...

static constexpr const CepsInt	_ICaL_factor = 3
	Index alias. More...

static constexpr const CepsInt	_INaL_factor = 4
	Index alias. More...

static constexpr const CepsInt	_nao = 5
	Index alias. More...

static constexpr const CepsInt	_cao = 6
	Index alias. More...

static constexpr const CepsInt	_ko = 7
	Index alias. More...

static constexpr const CepsInt	_R = 8
	Index alias. More...

static constexpr const CepsInt	_T = 9
	Index alias. More...

static constexpr const CepsInt	_F = 10
	Index alias. More...

static constexpr const CepsInt	_L = 11
	Index alias. More...

static constexpr const CepsInt	_rad = 12
	Index alias. More...

static constexpr const CepsInt	_vmyo_fraction = 13
	Index alias. More...

static constexpr const CepsInt	_vnsr_fraction = 14
	Index alias. More...

static constexpr const CepsInt	_vjsr_fraction = 15
	Index alias. More...

static constexpr const CepsInt	_vss_fraction = 16
	Index alias. More...

static constexpr const CepsInt	_drug = 17
	Index alias. More...

static constexpr const CepsInt	_ICNa = 18
	Index alias. More...

static constexpr const CepsInt	_hNa = 19
	Index alias. More...

static constexpr const CepsInt	_ICNaL = 20
	Index alias. More...

static constexpr const CepsInt	_hNaL = 21
	Index alias. More...

static constexpr const CepsInt	_ICto = 22
	Index alias. More...

static constexpr const CepsInt	_hto = 23
	Index alias. More...

static constexpr const CepsInt	_ICCal = 24
	Index alias. More...

static constexpr const CepsInt	_hCal = 25
	Index alias. More...

static constexpr const CepsInt	_ICKr = 26
	Index alias. More...

static constexpr const CepsInt	_hKr = 27
	Index alias. More...

static constexpr const CepsInt	_ICKs = 28
	Index alias. More...

static constexpr const CepsInt	_hKs = 29
	Index alias. More...

static constexpr const CepsInt	_ICK1 = 30
	Index alias. More...

static constexpr const CepsInt	_hK1 = 31
	Index alias. More...

static constexpr const CepsInt	_PKNa = 32
	Index alias. More...

static constexpr const CepsInt	_vcell = 0
	Index alias. More...

static constexpr const CepsInt	_ageo = 1
	Index alias. More...

static constexpr const CepsInt	_acap = 2
	Index alias. More...

static constexpr const CepsInt	_vmyo = 3
	Index alias. More...

static constexpr const CepsInt	_vnsr = 4
	Index alias. More...

static constexpr const CepsInt	_vjsr = 5
	Index alias. More...

static constexpr const CepsInt	_vss = 6
	Index alias. More...

static constexpr const CepsInt	_FRT = 7
	Index alias. More...

static constexpr const CepsInt	_gNaFrac = 8
	Index alias. More...

static constexpr const CepsInt	_gNaLFrac = 9
	Index alias. More...

static constexpr const CepsInt	_gtoFrac = 10
	Index alias. More...

static constexpr const CepsInt	_gCalFrac = 11
	Index alias. More...

static constexpr const CepsInt	_gKrFrac = 12
	Index alias. More...

static constexpr const CepsInt	_gKsFrac = 13
	Index alias. More...

static constexpr const CepsInt	_gK1Frac = 14
	Index alias. More...

Member Enumeration Documentation

◆ Type

enum ORdmD16::Type

strong

Model variant selector.

Enumerator
Endo	Model variant selector.
MidMyo	Model variant selector.
Epi	Model variant selector.

Definition at line 51 of file ORdmD16.hpp.

Constructor & Destructor Documentation

◆ ORdmD16()

ORdmD16::ORdmD16	(	const Type &	type,
		Unknown *	u,
		const CepsSet< CepsAttribute > &	attrs = `{}`,
		InputParameters *	params = `nullptr`
	)

Constructor (sets constants)

Definition at line 40 of file ORdmD16.cpp.

◆ ~ORdmD16()

ORdmD16::~ORdmD16 ( )

default

Destructor.

Member Function Documentation

◆ computeBgCurrents()

void ORdmD16::computeBgCurrents	(	CepsReal *	IKb,
		CepsReal *	INab,
		CepsReal *	ICab,
		CepsReal	v,
		CepsReal *	y
	)		const

protected

Background currents.

Definition at line 833 of file ORdmD16.cpp.

◆ computeICa()

void ORdmD16::computeICa	(	CepsReal *	ICaL,
		CepsReal *	ICaNa,
		CepsReal *	ICaK,
		CepsReal	v,
		CepsReal *	y,
		CepsReal *	dtyLin,
		CepsReal *	dtyNLin,
		CepsReal	fraction
	)		const

protected

L-type Ca2+ channel.

Definition at line 518 of file ORdmD16.cpp.

◆ computeIK1()

void ORdmD16::computeIK1	(	CepsReal *	IK1,
		CepsReal	v,
		CepsReal *	y,
		CepsReal *	dtyLin,
		CepsReal *	dtyNLin
	)		const

protected

Inward Rectifier K+ Current.

Definition at line 672 of file ORdmD16.cpp.

◆ computeIKr()

void ORdmD16::computeIKr	(	CepsReal *	IKr,
		CepsReal	v,
		CepsReal *	y,
		CepsReal *	dtyLin,
		CepsReal *	dtyNLin
	)		const

protected

Rapid Delayed Rectifier K+ Current.

Definition at line 607 of file ORdmD16.cpp.

◆ computeIKs()

void ORdmD16::computeIKs	(	CepsReal *	IKs,
		CepsReal	v,
		CepsReal *	y,
		CepsReal *	dtyLin,
		CepsReal *	dtyNLin
	)		const

protected

Slow Delayed Rectifier K+ Current.

Definition at line 640 of file ORdmD16.cpp.

◆ computeINa()

void ORdmD16::computeINa	(	CepsReal *	INa,
		CepsReal *	iNaL,
		CepsReal	v,
		CepsReal *	y,
		CepsReal *	dtyLin,
		CepsReal *	dtyNLin,
		CepsReal	fraction
	)		const

protected

Fast Na+ current and Late Na+ current.

Definition at line 395 of file ORdmD16.cpp.

◆ computeINaCa()

void ORdmD16::computeINaCa	(	CepsReal *	INaCa_i,
		CepsReal *	INaCa_ss,
		CepsReal	v,
		CepsReal *	y
	)		const

protected

Na+/Ca2+ exchanger.

Definition at line 700 of file ORdmD16.cpp.

◆ computeINaCaInternal()

CepsReal ORdmD16::computeINaCaInternal	(	CepsReal	v,
		CepsReal	na,
		CepsReal	ca
	)		const

protected

Internal function to avoid duplication.

Definition at line 708 of file ORdmD16.cpp.

◆ computeINaK()

void ORdmD16::computeINaK	(	CepsReal *	INaK,
		CepsReal	v,
		CepsReal *	y
	)		const

protected

Sodium/Potassium ATPase Current.

Definition at line 773 of file ORdmD16.cpp.

◆ computeIPCa()

void ORdmD16::computeIPCa	(	CepsReal *	IPCa,
		CepsReal *	y
	)		const

protected

Sarsolemmal calcium pump current.

Definition at line 855 of file ORdmD16.cpp.

◆ computeIto()

void ORdmD16::computeIto	(	CepsReal *	Ito,
		CepsReal	v,
		CepsReal *	y,
		CepsReal *	dtyLin,
		CepsReal *	dtyNLin,
		CepsReal	fraction
	)		const

protected

Transient outward K+ current.

Definition at line 464 of file ORdmD16.cpp.

◆ computeJrel()

void ORdmD16::computeJrel	(	CepsReal *	Jrel,
		CepsReal	ICaL,
		CepsReal *	y,
		CepsReal *	dtyLin,
		CepsReal *	dtyNLin,
		CepsReal	fraction
	)		const

protected

SR Calcium Release Flux, via Ryanodine Receptor.

Definition at line 862 of file ORdmD16.cpp.

◆ computeJup()

void ORdmD16::computeJup	(	CepsReal *	Jup,
		CepsReal *	y,
		CepsReal	fraction
	)		const

protected

Calcium Uptake via SERCA Pump.

Definition at line 894 of file ORdmD16.cpp.

◆ computeRates()

void ORdmD16::computeRates	(	CepsReal	t,
		CepsReal *	y,
		CepsReal *	v,
		CepsReal *	dtyL,
		CepsReal *	dtyNL,
		CepsReal *	dtv,
		DegreeOfFreedom *	dof
	)		const

overridevirtual

Get the linear and non linear part of the evolution function f. Also computes the ionic current.

Parameters

[in]	t	time
[in]	y	value of state variables at time
[in]	v	value of transmembrane voltage at time
[out]	dtyL	will be filled with the linear part of the derivative
[out]	dtyNL	the non linear part of the derivative
[out]	dtv	value of ionic current at time
[in]	dof	degree of freedom, in case some coefficients depend on space

Sarsolemmal calcium pump current

Implements AbstractIonicModel.

Definition at line 209 of file ORdmD16.cpp.

◆ getInitialCondition()

void ORdmD16::getInitialCondition	(	CepsReal *	v,
		CepsReal *	y
	)		const

finalvirtual

Sets initial values of state variables and transmembrane voltage for a single point. Arrays y,dty must be preallocated with size m_nStateVars.

Implements AbstractIonicModel.

Definition at line 163 of file ORdmD16.cpp.

◆ setupWithParameters()

void ORdmD16::setupWithParameters ( InputParameters * p )

protected

Sets the constants and the space dependant parameters from text inputs.

Definition at line 353 of file ORdmD16.cpp.

Field Documentation

◆ _a

constexpr const CepsInt ORdmD16::_a = 17

staticconstexprprotected

Index alias.

Definition at line 179 of file ORdmD16.hpp.

◆ _acap

constexpr const CepsInt ORdmD16::_acap = 2

staticconstexprprotected

Index alias.

Definition at line 241 of file ORdmD16.hpp.

◆ _ageo

constexpr const CepsInt ORdmD16::_ageo = 1

staticconstexprprotected

Index alias.

Definition at line 240 of file ORdmD16.hpp.

◆ _ap

constexpr const CepsInt ORdmD16::_ap = 20

staticconstexprprotected

Index alias.

Definition at line 182 of file ORdmD16.hpp.

◆ _cai

constexpr const CepsInt ORdmD16::_cai = 4

staticconstexprprotected

Index alias.

Definition at line 166 of file ORdmD16.hpp.

◆ _cajsr

constexpr const CepsInt ORdmD16::_cajsr = 7

staticconstexprprotected

Index alias.

Definition at line 169 of file ORdmD16.hpp.

◆ _CaMKt

constexpr const CepsInt ORdmD16::_CaMKt = 39

staticconstexprprotected

Index alias.

Definition at line 201 of file ORdmD16.hpp.

◆ _cansr

constexpr const CepsInt ORdmD16::_cansr = 6

staticconstexprprotected

Index alias.

Definition at line 168 of file ORdmD16.hpp.

◆ _cao

constexpr const CepsInt ORdmD16::_cao = 6

staticconstexprprotected

Index alias.

Definition at line 210 of file ORdmD16.hpp.

◆ _cass

constexpr const CepsInt ORdmD16::_cass = 5

staticconstexprprotected

Index alias.

Definition at line 167 of file ORdmD16.hpp.

◆ _d

constexpr const CepsInt ORdmD16::_d = 23

staticconstexprprotected

Index alias.

Definition at line 185 of file ORdmD16.hpp.

◆ _drug

constexpr const CepsInt ORdmD16::_drug = 17

staticconstexprprotected

Index alias.

Definition at line 221 of file ORdmD16.hpp.

◆ _F

constexpr const CepsInt ORdmD16::_F = 10

staticconstexprprotected

Index alias.

Definition at line 214 of file ORdmD16.hpp.

◆ _fcaf

constexpr const CepsInt ORdmD16::_fcaf = 26

staticconstexprprotected

Index alias.

Definition at line 188 of file ORdmD16.hpp.

◆ _fcafp

constexpr const CepsInt ORdmD16::_fcafp = 31

staticconstexprprotected

Index alias.

Definition at line 193 of file ORdmD16.hpp.

◆ _fcas

constexpr const CepsInt ORdmD16::_fcas = 27

staticconstexprprotected

Index alias.

Definition at line 189 of file ORdmD16.hpp.

◆ _ff

constexpr const CepsInt ORdmD16::_ff = 24

staticconstexprprotected

Index alias.

Definition at line 186 of file ORdmD16.hpp.

◆ _ffp

constexpr const CepsInt ORdmD16::_ffp = 30

staticconstexprprotected

Index alias.

Definition at line 192 of file ORdmD16.hpp.

◆ _FRT

constexpr const CepsInt ORdmD16::_FRT = 7

staticconstexprprotected

Index alias.

Definition at line 246 of file ORdmD16.hpp.

◆ _fs

constexpr const CepsInt ORdmD16::_fs = 25

staticconstexprprotected

Index alias.

Definition at line 187 of file ORdmD16.hpp.

◆ _gCalFrac

constexpr const CepsInt ORdmD16::_gCalFrac = 11

staticconstexprprotected

Index alias.

Definition at line 250 of file ORdmD16.hpp.

◆ _gK1Frac

constexpr const CepsInt ORdmD16::_gK1Frac = 14

staticconstexprprotected

Index alias.

Definition at line 253 of file ORdmD16.hpp.

◆ _gKrFrac

constexpr const CepsInt ORdmD16::_gKrFrac = 12

staticconstexprprotected

Index alias.

Definition at line 251 of file ORdmD16.hpp.

◆ _gKsFrac

constexpr const CepsInt ORdmD16::_gKsFrac = 13

staticconstexprprotected

Index alias.

Definition at line 252 of file ORdmD16.hpp.

◆ _gNaFrac

constexpr const CepsInt ORdmD16::_gNaFrac = 8

staticconstexprprotected

Index alias.

Definition at line 247 of file ORdmD16.hpp.

◆ _gNaLFrac

constexpr const CepsInt ORdmD16::_gNaLFrac = 9

staticconstexprprotected

Index alias.

Definition at line 248 of file ORdmD16.hpp.

◆ _gtoFrac

constexpr const CepsInt ORdmD16::_gtoFrac = 10

staticconstexprprotected

Index alias.

Definition at line 249 of file ORdmD16.hpp.

◆ _hCal

constexpr const CepsInt ORdmD16::_hCal = 25

staticconstexprprotected

Index alias.

Definition at line 229 of file ORdmD16.hpp.

◆ _hf

constexpr const CepsInt ORdmD16::_hf = 9

staticconstexprprotected

Index alias.

Definition at line 171 of file ORdmD16.hpp.

◆ _hK1

constexpr const CepsInt ORdmD16::_hK1 = 31

staticconstexprprotected

Index alias.

Definition at line 235 of file ORdmD16.hpp.

◆ _hKr

constexpr const CepsInt ORdmD16::_hKr = 27

staticconstexprprotected

Index alias.

Definition at line 231 of file ORdmD16.hpp.

◆ _hKs

constexpr const CepsInt ORdmD16::_hKs = 29

staticconstexprprotected

Index alias.

Definition at line 233 of file ORdmD16.hpp.

◆ _hL

constexpr const CepsInt ORdmD16::_hL = 15

staticconstexprprotected

Index alias.

Definition at line 177 of file ORdmD16.hpp.

◆ _hLp

constexpr const CepsInt ORdmD16::_hLp = 16

staticconstexprprotected

Index alias.

Definition at line 178 of file ORdmD16.hpp.

◆ _hNa

constexpr const CepsInt ORdmD16::_hNa = 19

staticconstexprprotected

Index alias.

Definition at line 223 of file ORdmD16.hpp.

◆ _hNaL

constexpr const CepsInt ORdmD16::_hNaL = 21

staticconstexprprotected

Index alias.

Definition at line 225 of file ORdmD16.hpp.

◆ _hs

constexpr const CepsInt ORdmD16::_hs = 10

staticconstexprprotected

Index alias.

Definition at line 172 of file ORdmD16.hpp.

◆ _hsp

constexpr const CepsInt ORdmD16::_hsp = 12

staticconstexprprotected

Index alias.

Definition at line 174 of file ORdmD16.hpp.

◆ _hto

constexpr const CepsInt ORdmD16::_hto = 23

staticconstexprprotected

Index alias.

Definition at line 227 of file ORdmD16.hpp.

◆ _ICaL_factor

constexpr const CepsInt ORdmD16::_ICaL_factor = 3

staticconstexprprotected

Index alias.

Definition at line 207 of file ORdmD16.hpp.

◆ _ICCal

constexpr const CepsInt ORdmD16::_ICCal = 24

staticconstexprprotected

Index alias.

Definition at line 228 of file ORdmD16.hpp.

◆ _ICK1

constexpr const CepsInt ORdmD16::_ICK1 = 30

staticconstexprprotected

Index alias.

Definition at line 234 of file ORdmD16.hpp.

◆ _ICKr

constexpr const CepsInt ORdmD16::_ICKr = 26

staticconstexprprotected

Index alias.

Definition at line 230 of file ORdmD16.hpp.

◆ _ICKs

constexpr const CepsInt ORdmD16::_ICKs = 28

staticconstexprprotected

Index alias.

Definition at line 232 of file ORdmD16.hpp.

◆ _ICNa

constexpr const CepsInt ORdmD16::_ICNa = 18

staticconstexprprotected

Index alias.

Definition at line 222 of file ORdmD16.hpp.

◆ _ICNaL

constexpr const CepsInt ORdmD16::_ICNaL = 20

staticconstexprprotected

Index alias.

Definition at line 224 of file ORdmD16.hpp.

◆ _ICto

constexpr const CepsInt ORdmD16::_ICto = 22

staticconstexprprotected

Index alias.

Definition at line 226 of file ORdmD16.hpp.

◆ _iF

constexpr const CepsInt ORdmD16::_iF = 18

staticconstexprprotected

Index alias.

Definition at line 180 of file ORdmD16.hpp.

◆ _iFp

constexpr const CepsInt ORdmD16::_iFp = 21

staticconstexprprotected

Index alias.

Definition at line 183 of file ORdmD16.hpp.

◆ _IK1_factor

constexpr const CepsInt ORdmD16::_IK1_factor = 2

staticconstexprprotected

Index alias.

Definition at line 206 of file ORdmD16.hpp.

◆ _IKr_factor

constexpr const CepsInt ORdmD16::_IKr_factor = 0

staticconstexprprotected

Index alias.

Definition at line 204 of file ORdmD16.hpp.

◆ _IKs_factor

constexpr const CepsInt ORdmD16::_IKs_factor = 1

staticconstexprprotected

Index alias.

Definition at line 205 of file ORdmD16.hpp.

◆ _INaL_factor

constexpr const CepsInt ORdmD16::_INaL_factor = 4

staticconstexprprotected

Index alias.

Definition at line 208 of file ORdmD16.hpp.

◆ _iS

constexpr const CepsInt ORdmD16::_iS = 19

staticconstexprprotected

Index alias.

Definition at line 181 of file ORdmD16.hpp.

◆ _iSp

constexpr const CepsInt ORdmD16::_iSp = 22

staticconstexprprotected

Index alias.

Definition at line 184 of file ORdmD16.hpp.

◆ _j

constexpr const CepsInt ORdmD16::_j = 11

staticconstexprprotected

Index alias.

Definition at line 173 of file ORdmD16.hpp.

◆ _jca

constexpr const CepsInt ORdmD16::_jca = 28

staticconstexprprotected

Index alias.

Definition at line 190 of file ORdmD16.hpp.

◆ _jp

constexpr const CepsInt ORdmD16::_jp = 13

staticconstexprprotected

Index alias.

Definition at line 175 of file ORdmD16.hpp.

◆ _Jrelnp

constexpr const CepsInt ORdmD16::_Jrelnp = 37

staticconstexprprotected

Index alias.

Definition at line 199 of file ORdmD16.hpp.

◆ _Jrelp

constexpr const CepsInt ORdmD16::_Jrelp = 38

staticconstexprprotected

Index alias.

Definition at line 200 of file ORdmD16.hpp.

◆ _ki

constexpr const CepsInt ORdmD16::_ki = 2

staticconstexprprotected

Index alias.

Definition at line 164 of file ORdmD16.hpp.

◆ _ko

constexpr const CepsInt ORdmD16::_ko = 7

staticconstexprprotected

Index alias.

Definition at line 211 of file ORdmD16.hpp.

◆ _kss

constexpr const CepsInt ORdmD16::_kss = 3

staticconstexprprotected

Index alias.

Definition at line 165 of file ORdmD16.hpp.

◆ _L

constexpr const CepsInt ORdmD16::_L = 11

staticconstexprprotected

Index alias.

Definition at line 215 of file ORdmD16.hpp.

◆ _m

constexpr const CepsInt ORdmD16::_m = 8

staticconstexprprotected

Index alias.

Definition at line 170 of file ORdmD16.hpp.

◆ _mL

constexpr const CepsInt ORdmD16::_mL = 14

staticconstexprprotected

Index alias.

Definition at line 176 of file ORdmD16.hpp.

◆ _nai

constexpr const CepsInt ORdmD16::_nai = 0

staticconstexprprotected

Index alias.

Definition at line 162 of file ORdmD16.hpp.

◆ _nao

constexpr const CepsInt ORdmD16::_nao = 5

staticconstexprprotected

Index alias.

Definition at line 209 of file ORdmD16.hpp.

◆ _nass

constexpr const CepsInt ORdmD16::_nass = 1

staticconstexprprotected

Index alias.

Definition at line 163 of file ORdmD16.hpp.

◆ _nca

constexpr const CepsInt ORdmD16::_nca = 29

staticconstexprprotected

Index alias.

Definition at line 191 of file ORdmD16.hpp.

◆ _PKNa

constexpr const CepsInt ORdmD16::_PKNa = 32

staticconstexprprotected

Index alias.

Definition at line 236 of file ORdmD16.hpp.

◆ _R

constexpr const CepsInt ORdmD16::_R = 8

staticconstexprprotected

Index alias.

Definition at line 212 of file ORdmD16.hpp.

◆ _rad

constexpr const CepsInt ORdmD16::_rad = 12

staticconstexprprotected

Index alias.

Definition at line 216 of file ORdmD16.hpp.

◆ _T

constexpr const CepsInt ORdmD16::_T = 9

staticconstexprprotected

Index alias.

Definition at line 213 of file ORdmD16.hpp.

◆ _vcell

constexpr const CepsInt ORdmD16::_vcell = 0

staticconstexprprotected

Index alias.

Definition at line 239 of file ORdmD16.hpp.

◆ _vjsr

constexpr const CepsInt ORdmD16::_vjsr = 5

staticconstexprprotected

Index alias.

Definition at line 244 of file ORdmD16.hpp.

◆ _vjsr_fraction

constexpr const CepsInt ORdmD16::_vjsr_fraction = 15

staticconstexprprotected

Index alias.

Definition at line 219 of file ORdmD16.hpp.

◆ _vmyo

constexpr const CepsInt ORdmD16::_vmyo = 3

staticconstexprprotected

Index alias.

Definition at line 242 of file ORdmD16.hpp.

◆ _vmyo_fraction

constexpr const CepsInt ORdmD16::_vmyo_fraction = 13

staticconstexprprotected

Index alias.

Definition at line 217 of file ORdmD16.hpp.

◆ _vnsr

constexpr const CepsInt ORdmD16::_vnsr = 4

staticconstexprprotected

Index alias.

Definition at line 243 of file ORdmD16.hpp.

◆ _vnsr_fraction

constexpr const CepsInt ORdmD16::_vnsr_fraction = 14

staticconstexprprotected

Index alias.

Definition at line 218 of file ORdmD16.hpp.

◆ _vss

constexpr const CepsInt ORdmD16::_vss = 6

staticconstexprprotected

Index alias.

Definition at line 245 of file ORdmD16.hpp.

◆ _vss_fraction

constexpr const CepsInt ORdmD16::_vss_fraction = 16

staticconstexprprotected

Index alias.

Definition at line 220 of file ORdmD16.hpp.

◆ _xk1

constexpr const CepsInt ORdmD16::_xk1 = 36

staticconstexprprotected

Index alias.

Definition at line 198 of file ORdmD16.hpp.

◆ _xrf

constexpr const CepsInt ORdmD16::_xrf = 32

staticconstexprprotected

Index alias.

Definition at line 194 of file ORdmD16.hpp.

◆ _xrs

constexpr const CepsInt ORdmD16::_xrs = 33

staticconstexprprotected

Index alias.

Definition at line 195 of file ORdmD16.hpp.

◆ _xs1

constexpr const CepsInt ORdmD16::_xs1 = 34

staticconstexprprotected

Index alias.

Definition at line 196 of file ORdmD16.hpp.

◆ _xs2

constexpr const CepsInt ORdmD16::_xs2 = 35

staticconstexprprotected

Index alias.

Definition at line 197 of file ORdmD16.hpp.

◆ m_type

Type ORdmD16::m_type

protected

Celltype selector (endo, epi, midmyo)

Definition at line 159 of file ORdmD16.hpp.

The documentation for this class was generated from the following files:

/builds/xxjFYZX3/0/carmen/ceps/src/ode/ionicModels/ORdmD16.hpp
/builds/xxjFYZX3/0/carmen/ceps/src/ode/ionicModels/ORdmD16.cpp

Detailed Description

Public Types

Public Member Functions

Protected Member Functions

Protected Attributes

Static Protected Attributes

Member Enumeration Documentation

◆ Type

Constructor & Destructor Documentation

◆ ORdmD16()

◆ ~ORdmD16()

Member Function Documentation

◆ computeBgCurrents()

◆ computeICa()

◆ computeIK1()

◆ computeIKr()

◆ computeIKs()

◆ computeINa()

◆ computeINaCa()

◆ computeINaCaInternal()

◆ computeINaK()

◆ computeIPCa()

◆ computeIto()

◆ computeJrel()

◆ computeJup()

◆ computeRates()

◆ getInitialCondition()

◆ setupWithParameters()

Field Documentation

◆ _a

◆ _acap

◆ _ageo

◆ _ap

◆ _cai

◆ _cajsr

◆ _CaMKt

◆ _cansr

◆ _cao

◆ _cass

◆ _d

◆ _drug

◆ _F

◆ _fcaf

◆ _fcafp

◆ _fcas

◆ _ff

◆ _ffp

◆ _FRT

◆ _fs

◆ _gCalFrac

◆ _gK1Frac

◆ _gKrFrac

◆ _gKsFrac

◆ _gNaFrac

◆ _gNaLFrac

◆ _gtoFrac

◆ _hCal

◆ _hf

◆ _hK1

◆ _hKr

◆ _hKs

◆ _hL

◆ _hLp

◆ _hNa

◆ _hNaL

◆ _hs

◆ _hsp

◆ _hto

◆ _ICaL_factor

◆ _ICCal

◆ _ICK1

◆ _ICKr

◆ _ICKs

◆ _ICNa

◆ _ICNaL

◆ _ICto

◆ _iF

◆ _iFp

◆ _IK1_factor

◆ _IKr_factor